Presence of orexin A and orexin 1 receptor in the buffalo prostate
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منابع مشابه
Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism
In accordance with the prominent role of orexins in the maintenance of wakefulness via activation of orexin-1 (OX1R) and orexin-2 (OX2R) receptors, various dual OX1/2R antagonists have been shown to promote sleep in animals and humans. While selective blockade of OX2R seems to be sufficient to initiate and prolong sleep, the beneficial effect of additional inhibition of OX1R remains controversi...
متن کاملOrexin directly excites orexin neurons through orexin 2 receptor.
Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R). Orexin B (1 μM) induced depolarization in orexin neurons, which was still observed in the presence of TTX (1 μM), AP-5 (50 μM), and CNQX (...
متن کاملOrexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B.
Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body weight by interacting with a complex array of bioactive peptides; however, there are no data as yet on the expression of orexin c...
متن کاملOrexin A and orexin receptor 1 axonal traffic in dorsal roots at the CNS/PNS interface
Hypothalamic orexin/hypocretin neurons send long axonal projections through the dorsal spinal cord in lamina I-II of the dorsal horn (DH) at the interface with the peripheral nervous system (PNS). We show that in the DH OXA fibers colocalize with substance P (SP) positive afferents of dorsal root ganglia (DRG) neurons known to mediate sensory processing. Further, OR1 is expressed in p75(NTR) an...
متن کاملAssesment of orexin receptor 1 in stress attenuated nociceptive behaviours in formalin test
Introduction: It is known that acute and chronic stress induce hormonal and neuronal changes which affecting both pain threshold and nociceptive behaviours. Orexin plays an important role in modulation of pain and stress. Considering pain modulation during stress and the role of orexin in pain and stress, orexin might be involved in pain modulation during stress.We evaluated the involvement ...
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ژورنال
عنوان ژورنال: Italian Journal of Animal Science
سال: 2007
ISSN: 1828-051X
DOI: 10.4081/ijas.2007.s2.794